The 6 keys by Jillian Michaels is a book on being healthy with a focus on the personal benefit of health being ageless strength health and beauty. I suspect that much of the book as well as Jillian Michaels 8 other buttocks are ghost written to a degree and in this case by Myatt Murphy.

First key in the book is named mastering your Macromolecules. Essentially this revolves around decreasing the damage of proteins in your body via free radicles. The second key is named engineering your epigenetics. This Kieu revolves around decreasing potential triggers to your genes such as pollutants elements in your diet and medications that may be harmful. The third key involves improving your stress by decreasing hidden stresses that you are not not fully aware of and increasing your resilience to stress. The fourth key is decreasing body inflammation. The fifth key is mastering your metabolism and a highlight of this chapter was the Rally against high-protein diets. Lastly the sixth key is tackling the telomeres which I found to be substantially similar to the first, second and fifth key.

Helpful information noted in this book included an understanding of MTOR that is upRegulated with high-protein diets. This correlates with prior book review on the gut barrier (The Good Gut) that mentions that chronic consumption of red meat will increase MTOR but occasional enjoyment does not. The mechanism of him tour in disease is that it decreases auto phage of cells that are old or senescent.

In the section of the book related to inflammation, it was helpful to explain that fat tissue releases inflammatory cytokines called adipokines thus the more fat tissue you have the higher your body inflammation will tend to be. On the other end of the spectrum excessive exercise can create a leaky gut barrier and the leaky gut barrier will logically mount an immune response and thus increased body inflammation as well. Interestingly anaerobic activity will stimulate hypoxia inducible factor in this will decrease chronic inflammation. This made me wonder if this may be an effective recommendation for those with autoimmune disease.

In the section on decreasing environmental effects, BPA in plastics and phthalates in scented products can affect (decrease) methylation of DNA. Abnormalities of DNA methylation is associated with cancer. 

In the section on stressors, decreasing body stressors in terms of physical, chemical, nutritional, and psycho spiritual are her recommendations. Other than evaluating the stressors to try to decrease them, she recommends framing stressors as lessons and learning. While other buttocks certainly go into more depth, finding purpose of life, being grateful, aspiring to your own personal goals, and approaching things with an open mind are common themes for authors on stress management.

In the metabolism chapter she reiterates what several other authors state is now a well substantiated principal that reduce calories increases longevity. She points to several studies in this regard. Page 110 and 111 described well the four nutrient sensing pathways of the body. It explains how excess energy source tells the body to not be concerned about using damaged cells as nutrients. The fourth pathway named Surtuins is regulated through NAD plus. A study from the University of Colorado was quoted in which 500 mg of nicotinamide riboside twice daily would increase in NAD+ by 60% and decrease blood pressure by 10 points.

There is a chapter on calorie reduction including determining your basal metabolic rate. However, this is written from a professional trainer standpoint and from other literature I am not persuaded at this point for a calorie reduction approach to weight loss. A mixed intermittent to true fasting approach with a change of eating patterns to whole foods which naturally keeps calories less and stimulates less hunger is would be what I would endorse.  I am not summarizing the information provided on decreasing calories through counting as this method is not persuasive as effective. I am also not endorsing the information she provides on various supplements with specific brands as the bulk of the literature supports using food as opposed to supplements is preferred and is the basis for benefits that supplement claims lean on. In that regard, there are a few useful points about supplements including the use of nicotinamide to stimulate NAD+ as well as glucosamine to interfere with glucose enzymes. By interfering with glucose enzymes glucosamine supports mitochondria using fat as an energy source instead. In my studies this decrease cancer and increased life expectancy and terms of 8 human years based on these mice studies. All author also mentions pickled food for its bacteria and Quercetin. The correlation of this to inhibition of histamine made me wonder if this could be recommended with those having histamine based allergic responses. Green tea was mentioned for its benefit through E 3G benefiting methylation. Resevetrol in red wine, red grapes, blueberries and dark chocolate for waking up sensecent (Zombie) cells through the SIRTI protein mechanism. Curry for curcumin?s benefit. Lastly, Rapamycin mentioned for stimulating cell recycling. Overall her approach to include medications and supplements may be considered by those looking to add something for health but the data that author presents indicates that less calories